Samples of matured and naturally growing sporophores of a wild macrofungus, M. xanthopus was collected from the natural vegetation from Shimoga district of Karnataka. This species was analyzed for its primary and secondary metabolites, physicochemical parameters and antimicrobial activities. Proteins, alkaloids, flavonoids, steroids, triterpenoids were present in all the sporophores except carbohydrates, polysaccharides, lipids, oils, glycosides, lignins, phenolics, tannins and saponins for screening of phytochemical studies. This mushroom was found to contain highest percentage of acid soluble ash content(43%) followed by moisture (27.6%), water soluble ash (13%), pH of 5 % w/v solution of aqueous extract (12.6 %), alcohol soluble extractive (10.5 %), foreign matter (5.9%) and total ash content (3.9%) for the physicochemical analysis. M. xanthopus showed highest antimicrobial activity against the two test cultures S.aureus and C.albicans. The chloroform and petroleum ether extracts inhibited the growth of these tested microorganisms and clear inhibition zones of 14 to 16 mm, and 12 to 14 mm in diameter was recorded. Chloroform extract revealed MIC value against S.aureus was similar to the standard antibiotic ampicillin (250 �µg /ml) and petroleum ether extract revealed MIC value against C.albicans was also similar to the standard greseofulvin (500�µg /ml).
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